Increased Levels of Branched-chain Amino Acid Associated With Increased Risk of Pancreatic Cancer in a Prospective Case-Control Study of a Large Cohort.Katagiri R, Goto A, Nakagawa T, Nishiumi S, Kobayashi T, Hidaka A, Budhathoki S, Yamaji T, Sawada N, Shimazu T, Inoue M, Iwasaki M, Yoshida M, Tsugane S. Gastroenterology. 2018 Aug 1. [Epub ahead of print]

BACKGROUND & AIMS:A marker is needed to identify individuals at risk for pancreatic cancer. Increases in branched-chain amino acids (BCAAs) have been associated with pancreatic cancer. We performed a prospective case-control study to study the association between plasma levels of BCAAs and risk of pancreatic cancer in a large cohort.

METHODS:We conducted a nested case-control study selected from 30,239 eligible participants, 40-69 years old within the Japan public health center-based prospective study. Over 16.4 years, 170 newly diagnosed pancreatic cancer cases were identified. Each case was matched to 2 controls by age, sex, geographic area, and fasting time at blood collection. The adjusted odds ratios (ORs) and 95% CIs for pancreatic cancer were calculated using conditional logistic regression models with adjustment for potential confounding factors.RESULTS:Increased plasma BCAA levels at baseline were associated with an increased risk of pancreatic cancer. Compared with the lowest quartile of BCAA levels, the OR in the highest quartile was 2.43 (95% CI, 1.21-4.90), and the OR per 1 standard deviation increase in BCAA levels was 1.32 (95% CI, 1.05-1.67). The association was especially strong among cases with blood samples collected 10 years or more before cancer diagnosis (OR per SD, 1.60; 95% CI, 1.10-2.32) compared to those detected less than 10 years before diagnosis (OR per SD, 1.16; 95% CI, 0.86-1.57).CONCLUSIONS:In an analysis of data from the Japan public health center-based prospective study, we found an association between increased plasma level of BCAA and an increased risk of pancreatic cancer-particularly when the increase in BCAAs was observed 10 years or more before diagnosis. These findings add to the growing body of evidence for the association between BCAA levels and pancreatic cancer risk. Leggi l'articolo

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