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Review article: 2014 UK consensus guidelines – hepatitis C management and direct-acting anti-viral therapy.M. H. Miller,K. Agarwal, A. Austin, A. Brown, S. T. Barclay, P. Dundas, G. M. Dusheiko, G. R. Foster, R. Fox, P. C. Hayes, C. Leen, C. Millson, S. D. Ryder, J. Tait, A. Ustianowski and J. F. Dillon .Alimentary Pharmacology & Therapeutics 2014 Article first published online: 22 APR 2014

Background

Therapeutic options for the management of hepatitis C virus (HCV) infection have evolved rapidly over the past two decades, with a consequent improvement in cure rates. Novel therapeutic agents are an area of great interest in the research community, with a number of these agents showing promise in the clinical setting.

American Gastroenterological Association Institute guideline on the use of thiopurines, methotrexate, and anti-TNF-α biologic drugs for the induction and maintenance of remission in inflammatory Crohn's disease.

Terdiman JP1, Gruss CB, Heidelbaugh JJ, Sultan S, Falck-Ytter YT; AGA Institute Clinical Practice and Quality Management Committee.

Collaborators (8)Dorn SD, Dudley-Brown SL, Lim JK, Palmer LB, Romero Y, Rubenstein JH, Weinberg DS, Yang YX. Gastroenterology. 2013 Dec;145(6):1459-63.

 

KEYWORDS: AGA, American Gastroenterological Association Institute, CD, Crohn's disease, Development and Evaluation, GRADE, Grading of Recommendations Assessment, PICO, TNF, and outcome, comparator, intervention, population, tumor necrosis factor

British Society of Gastroenterology guidelines on the diagnosis and management of Barrett's oesophagus .Rebecca C Fitzgerald, Massimiliano di Pietro, Krish Ragunath, et Al Gut 2014;63:7-42

These guidelines provide a practical and evidence-based resource for the management of patients with Barrett's oesophagus and related early neoplasia. The Appraisal of Guidelines for Research and Evaluation (AGREE II) instrument was followed to provide a methodological strategy for the guideline development.

Bacterial Infections in Cirrhosis. A Position Statement based on the EASL Special Conference 2013.

Jalan R, Fernandez J, Wiest R, Schnabl B, Moreau R, Angeli P, Stadlbauer V, Thierry Gustot T, Bernardi M, Canton R1, Agustin Albillos A, Lammert F, Wilmer A, Mookerjee R, Vila J, Garcia-Martinez R, Wendon J, Such J, Cordoba J, Sanyal A, Garcia-Tsao G, Arroyo V, Burroughs A, Ginès P. J Hepatol. 2014 Feb 11 [Epub ahead of print]

 

Bacterial infections are very common and represent one of the  most important reasons of progression of liver failure, development of liver-related complications, and mortality in patients with cirrhosis. In fact, bacterial infections may be a triggering factor for the occurrence of gastrointestinal bleeding, hypervolemic hyponatremia, hepatic encephalopathy, kidney failure, and development of acute-on-chronic liver failure.

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